In addition to comparing rural and non-rural assisted living residents' medication utilization, this study examined the prevalence of inappropriately prescribed medications (IPMs) and drug-to-drug interactions (DDIs) among residents of rural and non-rural assisted living facilities (ALFs). Residents of rural ALFs tended to be somewhat more impaired in physical functioning and cognitive status, and on average, took slightly more medications than their non-rural counterparts. Residents in rural ALFs appeared somewhat more likely to have an IPM and a DDI, a finding that, although not statistically significant, is consistent with their higher likelihood of taking more medications and their slightly lower likelihood of being in a facility with a RN on staff. Report available on request by contacting the Center.